Transcriptomics

Dataset Information

5

The BET inhibitor JQ1 selectively impairs the tumour response to hypoxia and downregulates CA9 and angiogenesis in triple receptor negative breast cancer


ABSTRACT: This study aimed to investigate whether the BET inhibitor JQ1 could alter the hypoxia-induced upregulation of gene expression and have an anti-tumour effect associated with this mechanism. We showed JQ1 downregulates 44% of hypoxia upregulated genes, including CA9 and VEGF-A. We demonstrated that JQ1 reduces triple receptor negative breast cancer (TNBC) tumour growth in monolayer and spheroid (3D) cell culture.

ORGANISM(S): Homo sapiens  

SUBMITTER: Syed Haider   Alan McIntyre  

PROVIDER: E-MTAB-4604 | ArrayExpress | 2016-03-31

REPOSITORIES: ArrayExpress

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