Dataset Information


Transcriptional response in acute lymphoblastic leukaemia cells to bone marrow microenvironment

ABSTRACT: Glucocorticoids (GCs) and topoisomerase II inhibitors are used in the treatment of acute lymphoblastic leukaemia (ALL) due to their ability to induce cell death in lymphoid cells. GC-induced apoptosis is mediated by the glucocorticoid receptor (GR), whereas topoisomerase II inhibitors cause DNA damage and activate sensors of DNA damage including the tumour suppressor p53. In order to shed light on the role of the microenvironment in cell death and identify determinants of drug sensitivity we performed transcriptomic analysis in ALL cells treated with the synthetic glucocorticoid dexamethasone, and the topoisomerase II inhibitor etoposide combined with bone marrow-derived conditioned media (CM).

ORGANISM(S): Homo sapiens  

SUBMITTER: Leo Zeef   

PROVIDER: E-MTAB-4761 | ArrayExpress | 2017-08-30


altmetric image


Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2014-06-02 | E-GEOD-38277 | ArrayExpress
2011-01-01 | E-GEOD-22973 | ArrayExpress
2018-09-28 | PXD011124 | Pride
2016-01-24 | E-GEOD-65028 | ArrayExpress
2016-01-24 | E-GEOD-65026 | ArrayExpress
2014-05-04 | E-GEOD-13145 | ArrayExpress
2014-06-02 | E-GEOD-33626 | ArrayExpress
2012-06-26 | E-GEOD-34572 | ArrayExpress
2014-07-23 | E-MTAB-858 | ArrayExpress
2016-03-19 | E-GEOD-79069 | ArrayExpress