Transcriptomics

Dataset Information

32

Transcriptional response in acute lymphoblastic leukaemia cells to bone marrow microenvironment


ABSTRACT: Glucocorticoids (GCs) and topoisomerase II inhibitors are used in the treatment of acute lymphoblastic leukaemia (ALL) due to their ability to induce cell death in lymphoid cells. GC-induced apoptosis is mediated by the glucocorticoid receptor (GR), whereas topoisomerase II inhibitors cause DNA damage and activate sensors of DNA damage including the tumour suppressor p53. In order to shed light on the role of the microenvironment in cell death and identify determinants of drug sensitivity we performed transcriptomic analysis in ALL cells treated with the synthetic glucocorticoid dexamethasone, and the topoisomerase II inhibitor etoposide combined with bone marrow-derived conditioned media (CM).

ORGANISM(S): Homo sapiens  

SUBMITTER: Leo Zeef  

PROVIDER: E-MTAB-4761 | ArrayExpress | 2017-08-30

REPOSITORIES: ArrayExpress

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