Transcriptomics

Dataset Information

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Variation in RNA expression in a panel of 30 breast cancer cell lines


ABSTRACT: RNA expression was measured using RNA sequencing in 30 different breast cancer cell lines, under untreated, exponentially growing conditions.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Bram Thijssen   Katarzyna Jastrzebski  

PROVIDER: E-MTAB-4801 | ArrayExpress | 2019-01-09

SECONDARY ACCESSION(S): ERP113092

REPOSITORIES: ArrayExpress, ENA

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Publications

Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines.

Jastrzebski Katarzyna K   Thijssen Bram B   Kluin Roelof J C RJC   de Lint Klaas K   Majewski Ian J IJ   Beijersbergen Roderick L RL   Wessels Lodewyk F A LFA  

Cancer research 20180529 15


Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a result of different oncogenic drivers and drug resistance mechanisms operating in each cell line. Although many of these mechanisms have been discovered, it remains a challenge to understand how they interact to render an individual cell line sensitive or resistant to a particular drug. To better understand this variability, we profiled a panel of 30 breast cancer cell lines in the absence of drugs for their mutations  ...[more]

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