Dataset Information

Promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

ABSTRACT: Array-based analysis of genome-wide DNA methylation changes in human CD34+ hematopoietic progenitor cells during myeloid differentiation and aging.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael T. Bocker

PROVIDER: E-MTAB-487 | ArrayExpress | 2011-03-17

REPOSITORIES: ArrayExpress

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Publications

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.

Bocker Michael T MT Hellwig Isabelle I Breiling Achim A Eckstein Volker V Ho Anthony D AD Lyko Frank F

Blood 20110322 19

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at distinct stages of hematopoiesis. We identified a defined set of differentiation-related genes that are methylated in CD34⁺ hematopoietic progenitor cells but show pronounced DNA hypo ...[more]

PMID: 21427290

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