Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael T. Bocker
PROVIDER: E-MTAB-487 | ArrayExpress | 2011-03-17
REPOSITORIES: ArrayExpress
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E-MTAB-487.README.txt | Txt | |||
E-MTAB-487.idf.txt | Idf | |||
E-MTAB-487.processed.1.zip | Processed | |||
E-MTAB-487.raw.1.zip | Raw | |||
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Bocker Michael T MT Hellwig Isabelle I Breiling Achim A Eckstein Volker V Ho Anthony D AD Lyko Frank F
Blood 20110322 19
DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at distinct stages of hematopoiesis. We identified a defined set of differentiation-related genes that are methylated in CD34⁺ hematopoietic progenitor cells but show pronounced DNA hypo ...[more]