Dataset Information


Transcription profiling of HL-60 acute myeloid leukemia cells treated with Daunorubicin (DNR), Cytarabin (Ara-C), or NADPH oxidase inhibitor VAS2870

ABSTRACT: Daunorubicin (DNR) and Cytarabin (Ara-C) are the main chemotherapeutic drugs used for Acute Myeloid Leukemias (AML) treatment. However, their mode of action is not well understood. To decipher if these drug would induce rapid transcriptional reprogramming, we treated HL-60 AML cell line with DNR or Ara-C for 3 hours and carried out a transcriptomic analyses. In addition, we had shown that Reactive Oxigen Species (ROS) produced by NADPH oxidases (NOX) are involved in DNR-induced gene expression. We therefore also performed a transcriptomic analyses in HL-60 cells treated with DNR and VAS2870, an NADPH oxidase inhibitor. HL-60 cells were treated or not for 3 hours with 2 µM Ara-C, 1 µM DNR or 1 µM DNR + 20µM VAS 2870. RNAs were purified from 3 independent experiments and used to probe Affymetrix Human Gene 2.0 ST Genechips

ORGANISM(S): Homo sapiens  

DISEASE(S): Acute Myeloid Leukemia


PROVIDER: E-MTAB-4895 | ArrayExpress | 2017-12-31


Dataset's files

Action DRS
E-MTAB-4895.idf.txt Idf Processed Raw
E-MTAB-4895.sdrf.txt Txt
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