Dataset Information


Transcription profiling of human glioblastoma cells with EGFR amplification grown in rat xenograft model

ABSTRACT: The gene expression profiles of two groups of triplicate human glioblastoma (GBM) xenografts grown in immunodeficient rats were compared. The first group of xenografts was derived from a patient biopsy with Epidermal Growth Factor Receptor (EGFR) amplification which grows highly invasive and is independent of angiogenesis. The second group was obtained by introducing a dominant-negative EGFR mutant into the tumor cells, leading to a progression of the tumors to an angiogenic phenotype associated with a transition from a proneural to a mesenchymal GBM molecular subtype.

INSTRUMENT(S): Affymetrix GeneChip Scanner 3000

ORGANISM(S): Homo sapiens  

SUBMITTER: Laurent Vallar   Hrvoje Miletic  

PROVIDER: E-MTAB-4898 | ArrayExpress | 2017-07-05


Similar Datasets

2017-07-01 | E-MTAB-4999 | ArrayExpress
2016-03-26 | E-MTAB-3487 | ArrayExpress
2017-11-29 | E-MTAB-5297 | ArrayExpress
2017-11-29 | E-MTAB-5299 | ArrayExpress
2014-07-11 | E-MTAB-1770 | ArrayExpress
2016-06-01 | E-GEOD-67665 | ArrayExpress
2015-04-10 | E-MTAB-3487 | ExpressionAtlas
2015-07-13 | E-MTAB-1770 | ExpressionAtlas
2017-03-01 | E-MTAB-4327 | ArrayExpress
2016-08-14 | E-GEOD-85577 | ArrayExpress