Transcriptomics

Dataset Information

45

Transcription profiling of human glioblastoma cells with EGFR amplification grown in rat xenograft model


ABSTRACT: The gene expression profiles of two groups of triplicate human glioblastoma (GBM) xenografts grown in immunodeficient rats were compared. The first group of xenografts was derived from a patient biopsy with Epidermal Growth Factor Receptor (EGFR) amplification which grows highly invasive and is independent of angiogenesis. The second group was obtained by introducing a dominant-negative EGFR mutant into the tumor cells, leading to a progression of the tumors to an angiogenic phenotype associated with a transition from a proneural to a mesenchymal GBM molecular subtype.

INSTRUMENT(S): Affymetrix GeneChip Scanner 3000

ORGANISM(S): Homo sapiens  

SUBMITTER: Laurent Vallar   Hrvoje Miletic  

PROVIDER: E-MTAB-4898 | ArrayExpress | 2017-07-05

REPOSITORIES: ArrayExpress

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