Transcriptomics

Dataset Information

344

Integrated host and viral transcriptome analysis by RNA-seq of specific pathogen-free chicken infected with Avian leukosis virus


ABSTRACT: Avian leukosis virus (ALV) causes substantial economic losses from mortality and decreased performance in poultry industry. To characterize the response to ALV challenge, we developed a novel methodology that combines four datasets: mRNA expression and their associated regulatory factors of miRNA and lncRNA, and ALV gene expression. Specific Pathogen-Free (SPF) layer chickens were assigned to the ALV-infected or control group. Spleen samples (n=6) were collected at 40 days post injection (dpi), and sequenced. Comparing the infected and non-infected groups, 864 genes, 7 miRNAs and 17 lncRNAs were differentially expressed.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Gallus gallus  

SUBMITTER: Xi Lan  

PROVIDER: E-MTAB-5135 | ArrayExpress | 2017-10-04

SECONDARY ACCESSION(S): ERP017744

REPOSITORIES: ArrayExpress, ENA

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