Dataset Information


ChIP-Seq of the Streptomyces venezuelae regulator BldD and its D116A mutant.

ABSTRACT: The dimerization and binding of DNA by BldD is affected by its interaction with cyclic di-GMP. The D116A mutant of BldD is partially impaired in its biding of cyclic di-GMP. ChIP-Seq was carried out to determine the difference in the degree of DNA binding by the wild type and D116A mutated BldD in Streptomyces venezuelae.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Streptomyces venezuelae  

SUBMITTER: Govind Chandra   Natalia Tschowri   Mark J Buttner  

PROVIDER: E-MTAB-5328 | ArrayExpress | 2017-11-01



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Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.

Bush Matthew J MJ   Bibb Maureen J MJ   Chandra Govind G   Findlay Kim C KC   Buttner Mark J MJ  

mBio 20130924 5

UNLABELLED:WhiA is a highly unusual transcriptional regulator related to a family of eukaryotic homing endonucleases. WhiA is required for sporulation in the filamentous bacterium Streptomyces, but WhiA homologues of unknown function are also found throughout the Gram-positive bacteria. To better understand the role of WhiA in Streptomyces development and its function as a transcription factor, we identified the WhiA regulon through a combination of chromatin immunoprecipitation-sequencing (ChIP  ...[more]

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