Transcriptomics

Dataset Information

44

Whole transcriptome profiling by microarray of monocytes stimulated with LPS and treated with trabectedin, lurbinectedin or doxorubicin


ABSTRACT: In order to assess the potential difference on the effect of lurbinectedin on monocytes compared to trabectedin, which has a selective killing effect (Germano et al., 2013), we performed a whole transcriptome assay on monocytes from healthy donors stimulated with LPS and with either trabectedin or lurbinectedin. Doxorubicin, an unrelated drug, was used as an internal control.

ORGANISM(S): Homo sapiens  

SUBMITTER: Luca Beltrame  

PROVIDER: E-MTAB-5366 | ArrayExpress | 2018-01-15

REPOSITORIES: ArrayExpress

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Publications

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models.

Belgiovine Cristina C   Bello Ezia E   Liguori Manuela M   Craparotta Ilaria I   Mannarino Laura L   Paracchini Lara L   Beltrame Luca L   Marchini Sergio S   Galmarini Carlos M CM   Mantovani Alberto A   Frapolli Roberta R   Allavena Paola P   D'Incalci Maurizio M  

British journal of cancer 20170706 5


BACKGROUND:Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian, BRCA1/2-mutated breast and small-cell lung cancer. Lurbinectedin is structurally related to trabectedin and it inhibits active transcription and the DNA repair machinery in tumour cells. METHODS:In this study we investigated whether lurbinectedin has the ability to modulate the inflammatory microenvironment and the viability of myeloid cells in t  ...[more]

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