Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Homo Sapiens Mus Musculus
SUBMITTER: Owen R Dando
PROVIDER: E-MTAB-5489 | ArrayExpress | 2017-02-16
SECONDARY ACCESSION(S): ERP021488
REPOSITORIES: ArrayExpress, ENA
Action | DRS | |||
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E-MTAB-5489.idf.txt | Idf | |||
E-MTAB-5489.sdrf.txt | Txt |
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Qiu Jing J McQueen Jamie J Bilican Bilada B Dando Owen O Magnani Dario D Punovuori Karolina K Selvaraj Bhuvaneish T BT Livesey Matthew M Haghi Ghazal G Heron Samuel S Burr Karen K Patani Rickie R Rajan Rinku R Sheppard Olivia O Kind Peter C PC Simpson T Ian TI Tybulewicz Victor Lj VL Wyllie David Ja DJ Fisher Elizabeth Mc EM Lowell Sally S Chandran Siddharthan S Hardingham Giles E GE
eLife 20161001
Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor. Rodent-based studies show that activity-dependent transcriptional programs mediate myriad functions in neuronal development, but the extent of their conservation in human neurons is unknown. We compared activity-dependent transcriptional responses i ...[more]