Dataset Information


Colony stimulating factor (CSF1) treatment of kidneys that have undergone ischemia reperfusion injury

ABSTRACT: Mice were subjected to renal artery clamps to induce ischemia/reperfusion injury to the kidney. 3 days post surgery mice were injected with CSF1 or PBS daily for a further 3 days. Mice were sacrificed 5 and 7 days post surgey and the kidney was removed and homogenised into single cell suspensions. Cells were selected on their expression of CD45, CD11b markers and the lack of CD11c. These cells were then subjected to microarray analyses to determine the global gene expresssion profiles of mice with and without treatment.

ORGANISM(S): Mus musculus  

SUBMITTER: Anthony Beckhouse   Sharon D Ricardo  

PROVIDER: E-MTAB-557 | ArrayExpress | 2011-06-20


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Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney wei  ...[more]

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