Transcriptomics

Dataset Information

70

Immune response eQTL study in primary human monocytes stimulated with multiple microbial ligands under multiple time points


ABSTRACT: Gene expression arrays and genotyping data in primary human monocytes from healthy individuals of European ancestry that have either been unstimulated (baseline), exposed to Lipopolysaccharide (90 minutes or 6 hours duration), muramyl-dipeptide (90 minutes or 6 hours duration) or transfected with 5’-triphosphate RNA (90 minutes or 6 hours duration). Please note that eQTL analysis methods and result files format are available as additional files attached to this experiment ( see https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-5631/files/ ).

ORGANISM(S): Homo sapiens  

SUBMITTER: Sarah Kim-Hellmuth  

PROVIDER: E-MTAB-5631 | ArrayExpress | 2017-05-16

REPOSITORIES: ArrayExpress

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Publications


Toll-like receptors (TLRs) play a key role in innate immunity. Apart from their function in host defense, dysregulation in TLR signalling can confer risk to autoimmune diseases, septic shock or cancer. Here we report genetic variants and transcripts that are active only during TLR signalling and contribute to interindividual differences in immune response. Comparing unstimulated versus TLR4-stimulated monocytes reveals 1,471 expression quantitative trait loci (eQTLs) that are unique to TLR4 stim  ...[more]

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