Dataset Information


RNA-seq of PDAC tissues grown as patient-derived tumor xenografts

ABSTRACT: Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. Patient-derived tumor xenografts (PDTXs) have been increasingly used as a prime approach for preclinical studies despite being insufficiently characterized as a model of the human disease and its diversity. Extensive multiomics characterization of these PDTXs have demonstrated their utility as a suitable model for preclinical studies, representing the diversity of the primary cancers. We performed a multi-factorial integrative analysis of genome-wide ChIP-seq on multiple histone modifications, as well as RNA-seq on subcutaneous PDTXs from 24 PDAC samples obtained either surgically or using diagnostic biopsies (endoscopic ultrasound guided fine needle aspirate). In the dataset, ChIP-seq for five distinct histone marks (H3K4me1, H3K27ac, H3K4me3, H3K27me3, and H3K9me3) and RNA-seq was carried out to generate new knowledge on the epigenetic landscapes underlying the heterogeneity of PDAC tissues grown in this manner.
Note: Sample phenotypes have been updated on 2020-09-11 to correct the swapped labels between "classical" and "basal" phenotypes.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

DISEASE(S): Pancreatic Adenocarcinoma

SUBMITTER: Gwen Lomberk   Krutika Satish Gaonkar   Asha Nair  

PROVIDER: E-MTAB-5639 | ArrayExpress | 2018-05-29



Dataset's files

Action DRS
E-MTAB-5639.idf.txt Idf
E-MTAB-5639.idf.txt_original Idf
E-MTAB-5639.sdrf.txt Txt
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