Dataset Information


Transcription profiling by array of reproductive tissues from female Cynomolgus macaques ( Macaca fascicularis ) after systemic vaccination with a modified vaccinia virus Ankara (MVA)-HIVB

ABSTRACT: The female reproductive tract is one of the major mucosal invasion site of HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the female reproductive tract after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized specific immune responses in all compartments of the female reproductive tract (FRT) of non-human primates after systemic vaccination. Memory T cells were preferentially found in the lower tract (vagina and cervix), whereas antigen-presenting cells and innate lymphoid cells were mainly located in the upper tract (uterus and fallopian tubes). This compartmentalisation of immune cells in the FRT was supported by transcriptomic analyses and correlation network. Polyfunctional MVA-specific CD8+ T cells were detected in the blood, lymph nodes, vagina, cervix, uterus and fallopian tubes. Anti-MVA IgG and IgA were detected in cervicovaginal fluid after a second vaccine dose. Systemic vaccination with an MVA vector thus elicits cellular and antibody responses in the female reproductive tract.

ORGANISM(S): Macaca fascicularis  

SUBMITTER: Romain Marlin   Elisabeth Menu   Nicolas Tchitchek  

PROVIDER: E-MTAB-5663 | ArrayExpress | 2017-06-09


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