Transcriptomics

Dataset Information

51

Transcription profiling by array of genetically engineered murine hepatoma Hepa8F5 cells with eight doxycylcline-inducible liver-enriched transcription factors to study transcription response under induced high liver function


ABSTRACT: We developed genetically engineered Hepa/8F5 cells (available from RIKEN BioResource Center [RCB4661]), in which genes of eight liver-enriched transcription factors (LETFs)—hepatocyte nuclear factor (HNF)-1α, HNF-1β, HNF-3β [FOXA2], HNF-4α, HNF-6, CCAAT/enhancer binding protein (C/EBP)-α, C/EBP-β and C/EBP-γ—were transduced into murine hepatoma Hepa1-6 cells as drug-inducible expression cassettes [Biochem. Eng. J., 60, 67–73 (2012)]. Hepa/8F5 cells can induce high liver functions by the addition of an inducer drug (doxycycline; Dox) via overexpression of LETF genes.

ORGANISM(S): Mus musculus  

SUBMITTER: Masamichi Kamihira  

PROVIDER: E-MTAB-5770 | ArrayExpress | 2017-11-15

REPOSITORIES: ArrayExpress

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