Genomics

Dataset Information

300

DNA-seq of human female Osteosarcoma U2OS cells to investigate Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE)


ABSTRACT: Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) in U2OS cells detected by SOLiD sequencing

INSTRUMENT(S): AB SOLiD 4 System

ORGANISM(S): Homo sapiens  

DISEASE(S): Osteosarcoma

SUBMITTER: Ian J Donaldson  

PROVIDER: E-MTAB-584 | ArrayExpress | 2011-11-03

SECONDARY ACCESSION(S): ERP000567

REPOSITORIES: ArrayExpress, ENA

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Publications

The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

Ji Zongling Z   Donaldson Ian J IJ   Liu Jingru J   Hayes Andrew A   Zeef Leo A H LA   Sharrocks Andrew D AD  

Molecular and Cellular Biology 20111114 2


The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in combinatorial transcriptional control with the AP-1 transcription factor. FOXK2 binding regions are widespread throughout the genome and are often coassociated with AP-1 bi  ...[more]

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