Transcriptomics

Dataset Information

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Gene expression microarray analysis of normal breast tissue biopsies


ABSTRACT: High mammographic density (MD) is associated with a 4-6 times increase in breast cancer risk. MD often decreases over time, but little is known about the corresponding biological mechanisms. We obtained biopsies from breasts of healthy women at two different time points years apart. After RNA isolation, Agilent Sureprint G3 Human Gene Expression 8x60K microarrays were performed. Mammographic density was calculated based on mammograms. We explored associations between clinical parameters, MD and gene expression and performed microenvironment tissue subtyping. Gene expression data from previous biopsies are deposited separately.

INSTRUMENT(S): Agilent C scanner

ORGANISM(S): Homo sapiens  

SUBMITTER: Helga Bergholtz  Vilde D Haakensen     

PROVIDER: E-MTAB-5885 | ArrayExpress | 2019-01-10

REPOSITORIES: ArrayExpress

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Publications

A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue.

Bergholtz Helga H   Lien Tonje Gulbrandsen TG   Ursin Giske G   Holmen Marit Muri MM   Helland Åslaug Å   Sørlie Therese T   Haakensen Vilde Drageset VD  

Journal of mammary gland biology and neoplasia 20190106


High mammographic density (MD) is associated with a 4-6 times increase in breast cancer risk. For post-menopausal women, MD often decreases over time, but little is known about the underlying biological mechanisms. MD reflects breast tissue composition, and may be associated with microenvironment subtypes previously identified in tumor-adjacent normal tissue. Currently, these subtypes have not been explored in normal breast tissue. We obtained biopsies from breasts of healthy women at two differ  ...[more]

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