Transcriptomics

Dataset Information

333

Bulk RNA-seq of dermal fibroblasts after stimulation with interferon or dsRNA (poly I:C)


ABSTRACT: Dermal fibroblasts from human, rhesus macaque, mouse and rat, stimulated with dsRNA (poly I:C), interferon and controls.
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable among responding cells, as well as to rapidly evolve in the course of mammal evolution. To study the transcriptional divergence and cell-to-cell variability of this response, we stimulated dermal fibroblast cells from two primates (human and macaque) and two rodents (mouse and rat) with dsRNA - a mimic of viral RNA that elicits a rapid innate immune response. Subsequently, we profiled the response using bulk RNA-seq, scRNA-seq and ChIP-seq across the four species and across different time points.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Musculus  

SUBMITTER: Tzachi Hagai  

PROVIDER: E-MTAB-5919 | ArrayExpress | 2018-07-06

SECONDARY ACCESSION(S): ERP024336

REPOSITORIES: ArrayExpress, ENA

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