Dataset Information


Comparative genomic hybridization by array of human paired xenograft and diagnosis T-cell Actute Lymphoblastic Leukemia samples

ABSTRACT: Arrays-CGH and/or SNP-array data from n=25 patients with T-ALL, including diagnosis, xenografted, remission and/or relapse samples (total 62 samples).

ORGANISM(S): Homo sapiens  

TISSUE(S): Xenograft, Bone Marrow, Blood, Whole Blood

DISEASE(S): Acute Lymphoblastic Leukemia,None

SUBMITTER: Jean Soulier  

PROVIDER: E-MTAB-593 | ArrayExpress | 2011-03-23


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Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse.

Clappier Emmanuelle E   Gerby Bastien B   Sigaux François F   Delord Marc M   Touzri Farah F   Hernandez Lucie L   Ballerini Paola P   Baruchel André A   Pflumio Françoise F   Soulier Jean J  

The Journal of experimental medicine 20110404 4

Genomic studies in human acute lymphoblastic leukemia (ALL) have revealed clonal heterogeneity at diagnosis and clonal evolution at relapse. In this study, we used genome-wide profiling to compare human T cell ALL samples at the time of diagnosis and after engraftment (xenograft) into immunodeficient recipient mice. Compared with paired diagnosis samples, the xenograft leukemia often contained additional genomic lesions in established human oncogenes and/or tumor suppressor genes. Mimicking such  ...[more]

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