Dataset Information


Transcription profiling by array of human hepatocarcinoma SMMC-7721 cells treated with a new compound IMB5043 against untreated controls

ABSTRACT: The whole human genome microarray was used for analysis of the differentially expressed genes in SMMC-7721 cells when exposed to 1 μM IMB5043 treatment for 24 h.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jianhua Gong  

PROVIDER: E-MTAB-6359 | ArrayExpress | 2018-01-22


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A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway.

Gong Jianhua J   Zheng Yanbo Y   Wang Ying Y   Sheng Weijin W   Li Yi Y   Liu Xiujun X   Si Shuyi S   Shao Rongguang R   Zhen Yongsu Y  

PloS one 20180202 2

Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy and the possible mechanism. By MTT assay, IMB5043 inhibited the proliferation of various human cancer cells lines, especially hepatocarcinoma SMMC-7721 cells. IMB5043 blocked cell cycle with G2/M arrest, induced cell apoptosis, and inhibited the migration and invasion of SMMC-7721  ...[more]

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