Transcriptomics

Dataset Information

76

ScRNA-seq of Mus musculus subcutaneous Lin- cells derived from the subcutaneous adipose stromal vascular fraction


ABSTRACT: We used the resolving power of single-cell transcriptional profiling to molecularly characterize the mouse adipose stem and progenitor cell-enriched, subcutaneous adipose stromal vascular fraction. We molecularly assessed CD45- CD31- SVF cells using the 10x Genomics Chromium (10x) platform.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus  

SUBMITTER: Petra Catalina Schwalie  

PROVIDER: E-MTAB-6677 | ArrayExpress | 2019-05-24

SECONDARY ACCESSION(S): ERP115300

REPOSITORIES: ArrayExpress, ENA

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Publications


Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities<sup>1,2</sup>. Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes<sup>3-14</sup>, our understanding of their in vivo origin and properties is incomplete<sup>2,15,16</sup>. This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots<sup>17</sup>, which has proven difficult to  ...[more]

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