Transcriptomics

Dataset Information

333

Bulk RNA-seq of of bone marrow derived mononuclear phagocytes


ABSTRACT: Dermal fibroblasts from mouse, rat, rabbit and pig, stimulated with LPS, with dsRNA (poly I:C), and controls.

INSTRUMENT(S): Illumina HiSeq 4000

SUBMITTER: Tzachi Hagai  

PROVIDER: E-MTAB-6773 | ArrayExpress | 2018-07-06

SECONDARY ACCESSION(S): ERP108377

REPOSITORIES: ArrayExpress, ENA

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Publications


As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the innate immune response's transcriptional divergence between species and variability in expression among cells. Using bulk and single-cell transcriptomics in fibroblasts and mononuc  ...[more]

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