Genomics

Dataset Information

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ChipSeq of conditional knock-in mouse carrying the R178E (EE) mutation in exon 5 of the endogenous mouse Trp53 gene locus.


ABSTRACT: The mouse R178E (EE) mutation of the Trp53 is a p53 mutant protein with native conformation that lacks the ability to form tetramers and thus constitutes a mutant form of p53 that lacks DNA binding cooperativity. Here we want to assess DNA binding ability of the EE mutant in MEFs under untreated conditions and following p53 stabilization with the Mdm2 inhibitor nutlin-3a and compare it to p53 KO and WT mice.

INSTRUMENT(S): Illumina HiSeq 1500

ORGANISM(S): Mus musculus  

SUBMITTER: Jean Schneikert   Andrea Nist   Julia Noll   Sabrina Elmshäuser   Kernt Köhler   Samet Mutlu   Marco Mernberger   Boris Klimovich   Boris Lamp   Oleg Timofeev   Thorsten Stiewe   Michael Wanzel  

PROVIDER: E-MTAB-6793 | ArrayExpress | 2019-09-03

SECONDARY ACCESSION(S): ERP108430

REPOSITORIES: ArrayExpress, ENA

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