Transcriptomics

Dataset Information

3

RNA-seq of group 1 Innate Lymphoid Cells (ILCs) in the mouse uterus and liver


ABSTRACT: We identified differences in the distribution of three group 1 ILC subsets in the mouse uterus. The dynamic distribution of g1 ILC subsets in the uterus at key stages of reproductive life may reflect subset-specific functions and emphasised the need for detailed characterisation of each subset

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus  

TISSUE(S): Uterus, Liver

SUBMITTER: Iva Filipovic1   Russell S Hamilton  

PROVIDER: E-MTAB-6812 | ArrayExpress | 2018-10-05

SECONDARY ACCESSION(S): ERP108974

REPOSITORIES: ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-MTAB-6812.idf.txt Idf
E-MTAB-6812.sdrf.txt Txt
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Publications


Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes<sup>+</sup>CD49a<sup>+</sup> NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with T  ...[more]

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