Dataset Information


RNA-seq of group 1 Innate Lymphoid Cells (ILCs) in the mouse uterus and liver

ABSTRACT: We identified differences in the distribution of three group 1 ILC subsets in the mouse uterus. The dynamic distribution of g1 ILC subsets in the uterus at key stages of reproductive life may reflect subset-specific functions and emphasised the need for detailed characterisation of each subset

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus  

TISSUE(S): Uterus, Liver

SUBMITTER: Iva Filipovic1   Russell S Hamilton  

PROVIDER: E-MTAB-6812 | ArrayExpress | 2018-10-05



Dataset's files

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E-MTAB-6812.idf.txt Idf
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Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes<sup>+</sup>CD49a<sup>+</sup> NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with T  ...[more]

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