Transcriptomics

Dataset Information

0

RNA-seq of human BR.1N and HaCaT cell lines treated with zebularine against untreated controls


ABSTRACT: The experimental design demonstrates that zebularine, a DNA methyltransferase inhibitor, promotes regeneration in the mouse and that retinoic acid and zebularine synergistically accelerate this process.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens  

SUBMITTER: Arkadiusz Piotrowski   Natalia Filipowicz   Alina Mieczkowska  

PROVIDER: E-MTAB-6832 | ArrayExpress | 2019-11-02

SECONDARY ACCESSION(S): ERP109064

REPOSITORIES: ArrayExpress, ENA

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BACKGROUND:Most studies on regenerative medicine focus on cell-based therapies and transplantations. Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensively investigated in regenerative research. It is known that healing potential decreases with development and developmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerative capacity. METHODS:We applied zebularine, a nucleoside inhibitor of DNA  ...[more]

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