Dataset Information


ATAC-seq of primary mesenchymal stem cell (MSC)-derived osteoblasts (differentiated with BMP2) from 4 human donors

ABSTRACT: ATAC-seq was performed to map open chromatin regions in hMSC-derived osteoblasts

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens  

SUBMITTER: Kurt Hankenson   Struan Grant   Yadav Wagley   Alessandra Chesi   Elisabetta Manduchi   Andrew Wells   Matthew Johnson  

PROVIDER: E-MTAB-6834 | ArrayExpress | 2019-03-20



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Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.

Chesi Alessandra A   Wagley Yadav Y   Johnson Matthew E ME   Manduchi Elisabetta E   Su Chun C   Lu Sumei S   Leonard Michelle E ME   Hodge Kenyaita M KM   Pippin James A JA   Hankenson Kurt D KD   Wells Andrew D AD   Grant Struan F A SFA  

Nature communications 20190319 1

Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-derived osteoblasts employing a massively parallel, high resolution Capture C based method in order to simultaneously characterize the genome-wide interactions of all human promoters.  ...[more]

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