Dataset Information


Transcription profiling by array of human colorectal cancer SW620 cells upon MSX1 depletion.

ABSTRACT: The first step in the development of human colorectal cancer (CRC) is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (APC) gene encoding an essential tumor suppressor. In order to identify genes affected by Apc loss, expression profiling of intestinal epithelium isolated from mice harboring the conditional allele of the gene was performed. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation. Subsequently, the expression pattern of human MSX1 was examined in a collection of colonic tumors. The MSX1 mRNA level was increased in all types of human intestinal neoplasia tested. In order to identify genes affected by MSX1 loss, expression profiling of human colorectal cancer cells SW620 upon MSX1 gene depletion was performed.

ORGANISM(S): Homo sapiens  

DISEASE(S): Colorectal Adenocarcinoma

SUBMITTER: Hynek Strnad   Monika Horazna   Vladimir Korinek   Michal Kolar  

PROVIDER: E-MTAB-6928 | ArrayExpress | 2019-11-01


Dataset's files

Action DRS
E-MTAB-6928.idf.txt Idf
E-MTAB-6928.idf.txt_original Idf Raw
E-MTAB-6928.sdrf.txt Txt
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