Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): Kennedy Disease,None
SUBMITTER: Bilal Malik
PROVIDER: E-MTAB-6986 | ArrayExpress | 2019-05-02
REPOSITORIES: ArrayExpress
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E-MTAB-6986.idf.txt | Idf | |||
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E-MTAB-6986.processed.1.zip | Processed | |||
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Malik Bilal B Devine Helen H Patani Rickie R La Spada Albert R AR Hanna Michael G MG Greensmith Linda L
Scientific reports 20190305 1
Spinal and bulbar muscular atrophy (SBMA) results from a CAG repeat expansion within the androgen receptor gene (AR). It is unclear why motor neurons selectively degenerate and there are currently no treatments for this debilitating disease. To uncover the causative genes and pathways involved in motor neuron dysfunction, we undertook transcriptomic profiling of primary embryonic motor neurons from SBMA mice. We show that transcriptional dysregulation occurs early during development in SBMA moto ...[more]