Transcriptomics

Dataset Information

21

ATAC-seq for L3.6pl cells


ABSTRACT: Identification of open chromatin regions in L3.6pl cells by ATAC-seq

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Feda H. Hamdan   Steven A. Johnsen  

PROVIDER: E-MTAB-7035 | ArrayExpress | 2018-12-18

SECONDARY ACCESSION(S): ERP109997

REPOSITORIES: ArrayExpress, ENA

altmetric image

Publications

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

Hamdan Feda H FH   Johnsen Steven A SA  

Proceedings of the National Academy of Sciences of the United States of America 20181212 52


Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advances in pancreatic cancer research uncovered various molecular subtypes with tumors expressing a squamous/basal-like gene expression signature displaying a worse prognosis. Through unbiased epigenome mapping, we identified deltaNp63 as a major driver of a gene signature in pancreatic cancer cell lines, which we report to faithfully represent the highly a  ...[more]

Similar Datasets

2018-12-18 | E-MTAB-7034 | ArrayExpress
2019-03-11 | E-MTAB-7746 | ArrayExpress
2019-07-08 | E-MTAB-7786 | ArrayExpress
2014-06-03 | E-GEOD-51746 | ArrayExpress
2015-05-22 | E-GEOD-61688 | ArrayExpress
2016-02-19 | E-GEOD-71214 | ArrayExpress
2014-06-26 | E-GEOD-57092 | ArrayExpress
2018-12-18 | E-MTAB-7033 | ArrayExpress
2014-11-03 | E-GEOD-53420 | ArrayExpress
2018-03-28 | E-MTAB-6594 | ArrayExpress