Transcriptomics

Dataset Information

0

ATAC-seq for L3.6pl cells


ABSTRACT: Identification of open chromatin regions in L3.6pl cells by ATAC-seq

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Feda H. Hamdan  Steven A. Johnsen     

PROVIDER: E-MTAB-7035 | ArrayExpress | 2018-12-18

SECONDARY ACCESSION(S): ERP109997

REPOSITORIES: ArrayExpress, ENA

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Publications

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

Hamdan Feda H FH   Johnsen Steven A SA  

Proceedings of the National Academy of Sciences of the United States of America 20181212 52


Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advances in pancreatic cancer research uncovered various molecular subtypes with tumors expressing a squamous/basal-like gene expression signature displaying a worse prognosis. Through unbiased epigenome mapping, we identified deltaNp63 as a major driver of a gene signature in pancreatic cancer cell lines, which we report to faithfully represent the highly a  ...[more]

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