Transcriptomics

Dataset Information

300

Methylation profiling of human colorectal carcinoma cells after inhibition of DNMT3B


ABSTRACT: Array-based analysis of genome-wide DNA methylation changes in colorectal carcinoma cells after inhibition of DNA methyltransferase 3B (DNMT3B)

ORGANISM(S): Homo sapiens  

DISEASE(S): Colorectal Adenocarcinoma

SUBMITTER: Sabine Hagemann  

PROVIDER: E-MTAB-719 | ArrayExpress | 2012-03-01

REPOSITORIES: ArrayExpress

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Publications

Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation.

Hagemann Sabine S   Kuck Dirk D   Stresemann Carlo C   Prinz Florian F   Brueckner Bodo B   Mund Cora C   Mumberg Dominik D   Sommer Anette A  

PloS one 20120501 5


Silencing of genes by hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic loci. However, the precise mechanisms underlying the establishment and maintenance of aberrant methylation marks are still elusive. The de novo DNA methyltransferase 3B (DNMT3B) has been suggested to play an important role in the generation of cancer-specific methylation patterns. Previous studies have shown that a reduction of DNMT3B protein levels in  ...[more]

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