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Transcriptomics

Dataset Information

23

Methylation profiling by array of cartilage tumors


ABSTRACT: In this study, a series of 102 cartilage tumors was used to uncover the molecular diversity of chondrosarcomas through the profiling of mRNA, miRNA, DNA methylation, DNA copy number aberrations and point mutations. An integrated classification using multiple molecular dimensions revealed three major molecular features unraveling the diversity in clinical outcome of chondrosarcoma: a high mitotic state, regional 14q32 loss of expression and IDH mutations leading to genome-wide hypermethylation. These three robust and simple molecular features classify chondrosarcoma in subtypes with superior clinical value as compared to the current grading system.

INSTRUMENT(S): Illumina iScan

ORGANISM(S): Homo sapiens  

SUBMITTER: Elarouci Nabila  

PROVIDER: E-MTAB-7263 | ArrayExpress | 2019-07-19

REPOSITORIES: ArrayExpress

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