Transcriptomics

Dataset Information

20

High-throughput sequencing of miRNA of cartilage tumors


ABSTRACT: In this study, a series of 102 cartilage tumors was used to uncover the molecular diversity of chondrosarcomas through the profiling of mRNA, miRNA, DNA methylation, DNA copy number aberrations and point mutations. An integrated classification using multiple molecular dimensions revealed three major molecular features unraveling the diversity in clinical outcome of chondrosarcoma: a high mitotic state, regional 14q32 loss of expression and IDH mutations leading to genome-wide hypermethylation. These three robust and simple molecular features classify chondrosarcoma in subtypes with superior clinical value as compared to the current grading system.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

DISEASE(S): Chondrosarcoma

SUBMITTER: Elarouci Nabila  

PROVIDER: E-MTAB-7265 | ArrayExpress | 2019-07-19

SECONDARY ACCESSION(S): ERP111275

REPOSITORIES: ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-MTAB-7265.idf.txt Idf
E-MTAB-7265.idf.txt_original Idf
E-MTAB-7265.sdrf.txt Txt
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