Dataset Information


Single-cell RNA-seq of CD4+ Treg and Tmem cells from different tissues in mouse (Chromium 10x data)

ABSTRACT: Non-lymphoid tissues (NLTs) harbour a pool of adaptive immune cells distinct from their counterparts in lymphoid tissues, and their development and phenotype remains largely unexplored. We used scRNA-seq to survey CD4+ T regulatory (Treg) and memory T (Tmem) cells in spleen, lymph nodes, skin and colon in an unbiased way, in mouse. This cross-tissues comparison allows us to obtain marker genes for immune populations in specific locations, as well as examine each population's heterogeneity. Additionally, a continuous phenotype of Treg migration can be modelled from the mouse data, unravelling the transcriptional stages through which these cells transition between tissues.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus  

SUBMITTER: Tomás Pires de Carvalho Gomes  

PROVIDER: E-MTAB-7311 | ArrayExpress | 2019-05-20



Similar Datasets

2018-06-25 | E-MTAB-6854 | ArrayExpress
2020-02-13 | E-MTAB-8077 | ArrayExpress
2018-05-24 | E-MTAB-6505 | ArrayExpress
2019-05-16 | E-MTAB-6487 | ArrayExpress
2020-08-27 | E-MTAB-9240 | ArrayExpress
2020-02-21 | E-MTAB-8581 | ArrayExpress
2020-01-01 | E-MTAB-8007 | ArrayExpress
2019-05-27 | E-MTAB-7149 | ArrayExpress
2018-07-09 | E-MTAB-6429 | ArrayExpress
2020-03-31 | E-MTAB-8119 | ArrayExpress