Transcriptomics

Dataset Information

34

Single cell RNA sequencing of putative AIRE+ dendritic cells from human paediatric tonsillitis


ABSTRACT: Characterisation and identification of putative human extra-thymic AIRE-expressing cells from paediatric tonsillitis samples using single -cell transcriptome profiling.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens  

SUBMITTER: Mike Morgan  

PROVIDER: E-MTAB-7381 | ArrayExpress | 2019-01-14

SECONDARY ACCESSION(S): ERP111686

REPOSITORIES: ArrayExpress, ENA

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Publications


Expression of the Autoimmune regulator (AIRE) outside of the thymus has long been suggested in both humans and mice, but the cellular source in humans has remained undefined. Here we identify AIRE expression in human tonsils and extensively analyzed these "extra-thymic AIRE expressing cells" (eTACs) using combinations of flow cytometry, CyTOF and single cell RNA-sequencing. We identified AIRE+ cells as dendritic cells (DCs) with a mature and migratory phenotype including high levels of antigen p  ...[more]

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