Transcriptomics

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SUMOylation promotes survival and integration of neural stem cell grafts in stroke


ABSTRACT: In this study we sought to determine the effect of overexpressing the SUMOylation E2 conjugase Ubc9 on the response of murine Neural Stem Cells (NSCs) to oxygen-glucose-deprivation and restoration of oxygen/glucose (OGD/ROG). We established stably-expandable lines of NSCs from the subventricular zones (SVZ) of adult wild-type mice (WT NSCs) and Ubc9-overexpressing mice (Ubc9 NSCs) and profiled their transcriptional changes in response to OGD/ROG as well as in response to differentiation.

ORGANISM(S): Mus musculus  

SUBMITTER: Tommaso Leonardi   Luca Peruzotti-Jametti  

PROVIDER: E-MTAB-7428 | ArrayExpress | 2019-04-11

REPOSITORIES: ArrayExpress

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