Transcriptomics

Dataset Information

17

Microarray of human primary CD16+ monocytes treated with fractalkine (CX3CL1) against untreated controls


ABSTRACT: This experiment is a part of the larger study on angiotensin II role in the upregulation of the CX3CL1 expression and its release in human first trimester placenta. CX3CL1 (or fractalkine) is chemokine involved in the pathogenesis of hypertension, which can be secreted by trophoblasts, initiating the cross talk with monocytes. Thus, we performed the microarray experiment to study the effects of recombinant human CX3CL1 on the transcriptome of human primary monocytes.

INSTRUMENT(S): GeneChip® Scanner 3000 7G

ORGANISM(S): Homo sapiens  

SUBMITTER: Florian Herse   Alina Frolova   Martin Gauster  

PROVIDER: E-MTAB-7484 | ArrayExpress | 2019-02-08

REPOSITORIES: ArrayExpress

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Publications

Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction.

Nonn Olivia O   Güttler Jacqueline J   Forstner Désirée D   Maninger Sabine S   Zadora Julianna J   Balogh András A   Frolova Alina A   Glasner Andreas A   Herse Florian F   Gauster Martin M  

International journal of molecular sciences 20190202 3


CX3CL1, which is a chemokine involved in many aspects of human pregnancy, is a membrane-bound chemokine shed into circulation as a soluble isoform. Placental CX3CL1 is induced by inflammatory cytokines and is upregulated in severe early-onset preeclampsia. In this study, the hypothesis was addressed whether angiotensin II can deregulate placental CX3CL1 expression, and whether CX3CL1 can promote a pro-inflammatory status of monocytes. qPCR analysis of human placenta samples (n = 45) showed stabl  ...[more]

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