Dataset Information


Transcriptional profiling of human macrophages differentiated with macrophage colony-stimulating factor (M-CSF) and/or granulocyte-macrophage colony-stimulating factor (GM-CSF)

ABSTRACT: In this study, we compared human monocytes differentiated for 7 days with M-CSF and/or GM-CSF. A comparison of the different macrophage populations was made using microarray profiling. Threshold: 1.0 . Logbase: 2 . Technology: Agilent.SingleColor.14850. Normalization: Shift to 75 percentile . Baseline Transformation: median of all samples . FlagSettings:. Feature is not Uniform:A. Feature is a population outlier:A. Feature is Saturated:A. Feature is not above background:M. Feature is not positive and significant:M.

ORGANISM(S): Homo sapiens  

SUBMITTER: Derek C Lacey  

PROVIDER: E-MTAB-791 | ArrayExpress | 2012-03-20


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Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models.

Lacey Derek C DC   Achuthan Adrian A   Fleetwood Andrew J AJ   Dinh Hang H   Roiniotis John J   Scholz Glen M GM   Chang Melody W MW   Beckman Sandra K SK   Cook Andrew D AD   Hamilton John A JA  

Journal of immunology (Baltimore, Md. : 1950) 20120430 11

GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations. The nature, extent, and generality of these differences were assessed by comparing the responses to these CSFs, either alone or in combination, in various human and murine macrophage lineage populations. The differences between the respective global gene expression profiles of macrophages, derived from human monocytes by GM-CSF or M-CSF, were compared with the differences between the respective profil  ...[more]

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