Transcriptomics

Dataset Information

0

RNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages


ABSTRACT: DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1F/-) riggers Golgi dispersal, dilation of endoplasmic reticulum, autophagy and exosome biogenesis leading to the secretion of extracellular vesicles (EVs) in vivo and ex vivo.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus  

SUBMITTER: Pantelis Topalis   George A Garinis  

PROVIDER: E-MTAB-8439 | ArrayExpress | 2019-11-04

SECONDARY ACCESSION(S): ERP117862

REPOSITORIES: ArrayExpress, ENA

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