Transcriptomics

Dataset Information

0

Single cell RNA on hemocytes from wandering larvae of Drosophila melanogaster not infested and infested by Leptopilina boulardi


ABSTRACT: We aimed at characterizing the diverse hemocyte populations present in the hemolymph of the Drosophila larvae. The hemocytes were collected from wandering larvae infested by wasp (WI) or not infested (NI). The hemocytes were then sequenced using 10x genomics technology.

INSTRUMENT(S): Chromium Single Cell 3’ Reagent kits v2, Illumina HiSeq 4000

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: P B Cattenoz   A Giangrande  

PROVIDER: E-MTAB-8698 | ArrayExpress | 2020-03-12

SECONDARY ACCESSION(S): ERP119519

REPOSITORIES: ArrayExpress, ENA

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Publications

Temporal specificity and heterogeneity of Drosophila immune cells.

Cattenoz Pierre B PB   Sakr Rosy R   Pavlidaki Alexia A   Delaporte Claude C   Riba Andrea A   Molina Nacho N   Hariharan Nivedita N   Mukherjee Tina T   Giangrande Angela A  

The EMBO journal 20200312 12


Immune cells provide defense against non-self and have recently been shown to also play key roles in diverse processes such as development, metabolism, and tumor progression. The heterogeneity of Drosophila immune cells (hemocytes) remains an open question. Using bulk RNA sequencing, we find that the hemocytes display distinct features in the embryo, a closed and rapidly developing system, compared to the larva, which is exposed to environmental and metabolic challenges. Through single-cell RNA  ...[more]

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