Transcriptomics

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Comparative gene expression profiling of Drosophila primary neuronal cultures expressing or not the human Tau0N4RWT protein


ABSTRACT: Deciphering the pathophysiological mechanisms that lead from the alteration of human Tau biology to neuronal death in tauopathies including Alzheimer's disease (AD), fronto-temporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Pick's disease (PiD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) depends notably on the identification of Tau cellular partners and a better understanding of Tau functions. In this aim, we performed gene expression profiling to identify upregulated and downregulated genes in response to ectopic induced expression for 3 days of human Tau0N4RWT protein in Drosophila primary neuronal cultures from Elav-GAL4GS larval brains.

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Magalie LECOURTOIS   Sebastien FEUILLETTE  

PROVIDER: E-MTAB-8712 | ArrayExpress | 2020-02-11

REPOSITORIES: ArrayExpress

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