Dataset Information


Bulk RNA-seq of the human fetal neocortex, lateral ganglionic eminence and medial ganglionic eminence at 7, 9, 11 and 20 post-conceptional weeks

ABSTRACT: Deep transcriptional profiling of the human neocortex, lateral ganglionic eminence (LGE) and medial ganglionic eminences (MGE), from 7 to 20 post-conceptional weeks (pcw), for de novo lincRNAs discovery and to establish a unique coding and non-coding gene signature for the three different regions.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo Sapiens

TISSUE(S): Striatum, Lateral Ganglionic Eminence, Neocortex, Medial Ganglionic Eminences

SUBMITTER: Dario Besusso   Massimiliano Pagani   Dan Felsenfeld   Paola Conforti   Marco De Simone   Elena Vezzoli   Romina Vuono   Vittoria D Bocchi   Xiaoling He   Raoul JP Bonnal   Ira Espuny-Camacho   Andrea Faedo   Jian Chen   Valeria Ranzani   Giulio Pavesi   Federica Gervasoni   Grazisa Rossetti   Elena Cattaneo   Roger A Barker   Claudio Cappodona 

PROVIDER: E-MTAB-8893 | ArrayExpress | 2021-05-13



Dataset's files

Action DRS
E-MTAB-8893.idf.txt Idf
E-MTAB-8893.idf.txt_original Idf Processed
E-MTAB-8893.sdrf.txt Txt
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Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of 1116 long intergenic noncoding RNAs (lincRNAs) identified de novo and then profiled 96,789 single cells from the early human fetal striatum. We found that D1 and D2 medium spiny neurons (D1- and D2-MSNs) arise from a common progenitor and that lineage commitment is establish  ...[more]

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