Transcriptomics

Dataset Information

4

RNA-seq of RBC depleted whole blood from COVID-19 patients and controls


ABSTRACT: Red blood cells (RBC) depleted whole blood from COVID-19 patients and controls was harvested and processed in order to performed 10X single cell RNA-seq. For COVID-19 patients 2 samples 10 days a part were analyzed.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens  

SUBMITTER: Aymeric Silvin  

PROVIDER: E-MTAB-9221 | ArrayExpress | 2020-08-21

SECONDARY ACCESSION(S): ERP122394

REPOSITORIES: ArrayExpress, ENA

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Publications

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.

Silvin Aymeric A   Chapuis Nicolas N   Dunsmore Garett G   Goubet Anne-Gaëlle AG   Dubuisson Agathe A   Derosa Lisa L   Almire Carole C   Hénon Clémence C   Kosmider Olivier O   Droin Nathalie N   Rameau Philippe P   Catelain Cyril C   Alfaro Alexia A   Dussiau Charles C   Friedrich Chloé C   Sourdeau Elise E   Marin Nathalie N   Szwebel Tali-Anne TA   Cantin Delphine D   Mouthon Luc L   Borderie Didier D   Deloger Marc M   Bredel Delphine D   Mouraud Severine S   Drubay Damien D   Andrieu Muriel M   Lhonneur Anne-Sophie AS   Saada Véronique V   Stoclin Annabelle A   Willekens Christophe C   Pommeret Fanny F   Griscelli Frank F   Ng Lai Guan LG   Zhang Zheng Z   Bost Pierre P   Amit Ido I   Barlesi Fabrice F   Marabelle Aurélien A   Pène Frédéric F   Gachot Bertrand B   André Fabrice F   Zitvogel Laurence L   Ginhoux Florent F   Fontenay Michaela M   Solary Eric E  

Cell 20200805 6


Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk patients. Thus, we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14<sup>Low</sup>CD16<sup>High</sup> monocytes, accumulation of HLA  ...[more]

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