Transcriptomics

Dataset Information

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Bulk RNA-seq of Anopheles gambiae hemocytes, guts, and carcasses after blood-feeding, Plasmodium berghei infection, or sugar feeding


ABSTRACT: Anopheline mosquitoes transmit Plasmodium parasites to humans, and are responsible for an estimated 219 million cases of malaria, leading to over 400,000 deaths annually. The mosquito’s immune system limits Plasmodium infection in several ways, and hemocytes, the insect white blood cells, are key players in these defense responses. However, the full functional diversity of mosquito hemocytes and their developmental trajectories have not been established. We use bulk RNA sequencing (scRNA-seq) to analyze the transcriptional profiles of hemocytes, of guts, and of carcasses of mosquito hemocytes in response to blood feeding or infection with Plasmodium. Data from three independent biological replicates for each condition and time-point (day 0, 1, 2, 3, and 7 after sugar-feeding, blood-feeding or P. berghei infection).

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Anopheles gambiae  

SUBMITTER: Gianmarco Raddi   Oliver Billker  

PROVIDER: E-MTAB-9241 | ArrayExpress | 2020-08-27

SECONDARY ACCESSION(S): ERP122460

REPOSITORIES: ArrayExpress, ENA

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