Dataset Information


Human keratinocyte sensitizing potential

ABSTRACT: HaCaT human keratinocytes were exposed for 4 hours to 26 compounds at a concentration that resulted in 20% cell death after 24 hours of exposure.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jochem W van der Veen  

PROVIDER: E-MTAB-943 | ArrayExpress | 2012-12-04


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Applicability of a keratinocyte gene signature to predict skin sensitizing potential.

van der Veen Jochem W JW   Pronk Tessa E TE   van Loveren Henk H   Ezendam Janine J  

Toxicology in vitro : an international journal published in association with BIBRA 20120828 1

There is a need to replace animal tests for the identification of skin sensitizers and currently many alternative assays are being developed that have very promising results. In this study a gene signature capable of very accurate identification of sensitizers was established in the HaCaT human keratinocyte cell line. This signature was evaluated in a separate study using six chemicals that are either local lymph node (LLNA) false-positive or false-negative chemicals in addition to nine sensitiz  ...[more]

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