Transcriptomics

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Comparison of receptor tyrosine kinase (RTK) family gene expression between normoxic cells and hypoxia-induced gefitinib resistant clones


ABSTRACT: In this study, we explored the mechanisms of hypoxia-induced EGFR TKI resistance in non-small cell lung cancer (NSCLC) harbored activating EGFR mutation. The NSCLC cell lines were exposed to normorxia or 1% oxygen for 4 weeks, and then we tested EGFR TKI sensitivity in normoxic and hypoxic NSCLC cell lines. In this microarray experiment, we used normoxic HCC827 and hypoxia-induced gefitinib resistant clones, C2-3 and C2-10. Those clones were selected with gefitinib treatment after the HCC827 were exposed to 1% oxygen for 4 weeks, and the HCC827 C2-3 and C2-10 clones were selected at random for this study.

ORGANISM(S): Homo sapiens  

DISEASE(S): Lung Adenocarcinoma

SUBMITTER: Yuhong Lu  

PROVIDER: E-MTAB-9452 | ArrayExpress | 2020-12-19

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-9452.idf.txt Idf
E-MTAB-9452.idf.txt_original Idf
E-MTAB-9452.raw.1.zip Raw
E-MTAB-9452.sdrf.txt Txt
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