Transcriptomics

Dataset Information

238

Transcription profiling by array of IL-10+IL-4+ versus IL-10_IL-4+ cells from Foxp3null mice.


ABSTRACT: Comparison of IL-10+IL-4+ versus IL-10_IL-4+ cells from Foxp3null mice, sorted by secreted cytokine capture staining.

ORGANISM(S): Mus musculus  

SUBMITTER: A John Altin  

PROVIDER: E-MTAB-948 | ArrayExpress | 2012-03-15

REPOSITORIES: ArrayExpress

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Publications

IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.

Altin John A JA   Goodnow Chris C CC   Cook Matthew C MC  

Journal of immunology (Baltimore, Md. : 1950) 20120430 11


Activated Th cells influence other T cells via positive feedback circuits that expand and polarize particular types of response, but little is known about how they may also initiate negative feedback against immunopathological reactions. In this study, we demonstrate the emergence, during chronic inflammation, of GATA-3(+) Th2 inhibitory (Th2i) cells that express high levels of inhibitory proteins including IL-10, CTLA-4, and granzyme B, but do so independently of Foxp3. Whereas other Th2 effect  ...[more]

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