Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo sapiens
SUBMITTER: Christian Sommerauer
Claudia Kutter
PROVIDER: E-MTAB-9711 | ArrayExpress | 2020-11-18
SECONDARY ACCESSION(S): ERP124749
REPOSITORIES: ArrayExpress, ENA
Stebbing Justin J Sánchez Nievas Ginés G Falcone Marco M Youhanna Sonia S Richardson Peter P Ottaviani Silvia S Shen Joanne X JX Sommerauer Christian C Tiseo Giusy G Ghiadoni Lorenzo L Virdis Agostino A Monzani Fabio F Rizos Luis Romero LR Forfori Francesco F Avendaño-Céspedes Almudena A De Marco Salvatore S Carrozzi Laura L Lena Fabio F Sánchez-Jurado Pedro Manuel PM Lacerenza Leonardo Gianluca LG Cesira Nencioni N Caldevilla-Bernardo David D Perrella Antonio A Niccoli Laura L Méndez Lourdes Sáez LS Matarrese Daniela D Goletti Delia D Tan Yee-Joo YJ Monteil Vanessa V Dranitsaris George G Cantini Fabrizio F Farcomeni Alessio A Dutta Shuchismita S Burley Stephen K SK Zhang Haibo H Pistello Mauro M Li William W Mas Romero Marta M Andrés Pretel Fernando F Simón-Talero Rafaela Sánchez RS García-Molina Rafael R Kutter Claudia C Felce James H JH Nizami Zehra F ZF Miklosi Andras G AG Penninger Josef M JM Menichetti Francesco F Mirazimi Ali A Abizanda Pedro P Lauschke Volker M VM
Science advances 20201113
Using AI we identified baricitinib as possessing anti-viral and anti-cytokine efficacy. We now show a 71% (95% CI 0.15-0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age 81 years). A further 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-alpha-2 (IFNα2) significantly increases ACE ...[more]