Dataset Information


Transcription profiling of wild type mouse lung after treatement with Bleomycin hydrogen chloride to examine disease progression in pulmonary fibrosis

ABSTRACT: Pulmonary fibrosis was induced by a single tail vein injection of Bleomycin hydrogen chloride (100 mg/kg body weight; 1/3 LD50; Nippon Kayaku Co. Ltd., Tokyo) to 6- to 8-wk-old mice. Mice (3-5/endpoint) were sacrificed 7, 15 and 23 days post Bleomycin administration and RNA samples were extracted from sagittal sections of the left lung lobes. Pooled RNA samples, after reverse transcription and labeling, were hybridized to cDNA microarrays, manufactured by RIKEN, containing 21168 gene probes.

ORGANISM(S): Mus musculus  

SUBMITTER: Vaggelis Harokopos  

PROVIDER: E-MUGN-1 | ArrayExpress | 2008-03-06


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Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia-inducible factor-1alpha in disease pathogenesis.

Tzouvelekis Argyris A   Harokopos Vaggelis V   Paparountas Triantafillos T   Oikonomou Nikos N   Chatziioannou Aristotelis A   Vilaras George G   Tsiambas Evangelos E   Karameris Andreas A   Bouros Demosthenes D   Aidinis Vassilis V  

American journal of respiratory and critical care medicine 20070829 11

RATIONALE: Despite intense research efforts, the etiology and pathogenesis of idiopathic pulmonary fibrosis remain poorly understood. OBJECTIVES: To discover novel genes and/or cellular pathways involved in the pathogenesis of the disease. METHODS: We performed expression profiling of disease progression in a well-characterized animal model of the disease. Differentially expressed genes that were identified were compared with all publicly available expression profiles both from human patients an  ...[more]

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