Transcriptomics

Dataset Information

36

Transcription profiling of human follicular lymphoma and normal lymphoid tissue comparisons


ABSTRACT: 20 FL lymph node samples from 16 patients and four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Data can be viewed on the supplemental website at http://genome-www.stanford.edu/rituximab/.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter  Sean Bohen     

PROVIDER: E-SMDB-1845 | ArrayExpress| 2012-03-27

REPOSITORIES: ArrayExpress

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Publications

Variation in gene expression patterns in follicular lymphoma and the response to rituximab.

Bohen Sean P SP   Troyanskaya Olga G OG   Alter Orly O   Warnke Roger R   Botstein David D   Brown Patrick O PO   Levy Ronald R  

Proceedings of the National Academy of Sciences of the United States of America 20030205 4


Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from ri  ...[more]

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