Transcriptomics

Dataset Information

46

Transcription profiling of human genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome


ABSTRACT:

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Paul-Martin Holterhus  

PROVIDER: E-SMDB-2121 | ArrayExpress | 2006-06-06

REPOSITORIES: ArrayExpress

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Publications

Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor.

Holterhus Paul-Martin PM   Hiort Olaf O   Demeter Janos J   Brown Patrick O PO   Brooks James D JD  

Genome biology 20030515 6


BACKGROUND: Androgen insensitivity syndrome (AIS) comprises a range of phenotypes from male infertility to complete feminization. Most individuals with AIS carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, we used genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations to gain insights into the role of the AR in human genital differentiati  ...[more]

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